Skp2, also known as S-phase kinase-associated protein 2, is a key regulator of cell cycle progression and cell growth. It plays a critical role in the ubiquitin-proteasome pathway, where it targets several key cell cycle regulators for degradation. In addition, Skp2 has been linked to various human cancers, as its overexpression can lead to uncontrolled cell proliferation. Researchers have been studying the functions and regulatory mechanisms of Skp2 to better understand its role in cancer development and identify potential therapeutic targets. English short sentences and example examples related to Skp2 provide valuable insight into its biological functions and its implications for human health.
Skp2(细胞S期激酶相关蛋白),S-phase kinase-associated protein 2(Skp2)
1)S-phase kinase-associated protein 2(Skp2)Skp2(细胞S期激酶相关蛋白)
2)S-phase kinase associated protein 2(Skp2)S期激酶相关蛋白2(Skp2)
3)S-Phase Kinase-Associated Proteins 2 (Skp2)S期激酶相关蛋白(Skp2)
4)S-phase kinase associated protein 2细胞周期S期激酶相关蛋白2
5)Skp2细胞S期激酶相关蛋白2
英文短句/例句
1.Expression of Cell S-phase Kinase Associated Protein 2 in Lung Carcinoma and Its Correlation to the Prognosis.;细胞S期激酶相关蛋白2在肺癌中的表达及其与预后的关系
2.Changes of Kinase-Associated Protein 2 During S Phase of Rat Mesangial Cells Proliferation大鼠系膜细胞增殖时S期激酶相关蛋白2表达的变化及机制
3.The Effection of Skp2 shRNA on the Apoptosis and Proliferation of K562 CellsRNA干扰技术阻断S期激酶相关蛋白2表达对K562细胞增殖和凋亡的影响
4.Expression of S-phase kinase-interacing protein 2 in esophageal squamous carcinoma and its clinical significanceS期激酶相关蛋白2在食管癌中的表达及其意义
5.Relation between cyclin dependent kinase inhibitor and tumors:recent progress细胞周期蛋白依赖性激酶抑制剂与肿瘤相关性的研究进展
6.Expressions and Significance of COX-2,CDK2 to Human Gastric Carcinoma环氧化酶2、细胞周期调节蛋白依耐性激酶CDK2在胃癌中的表达
7.Crosstalk Between Nitric Oxide,Ca~(2+) and Protein Kinases in Plant Cells植物细胞NO,Ca~(2+)和蛋白激酶的信号交叉
8.Related research between mast cell and intestinal proteinase activated receptor-2,NF-κB expressed in intestinal mucosa of patients with ulcerative colitis蛋白酶激活受体2、NF-κB在溃疡性结肠炎肠黏膜的表达及其与肥大细胞相关性研究
9.Reversion transcriptional expression of DAPK in bladder cancer T24 cells 5-aza-2"-deoxycytidine5-杂氮脱氧胞苷逆转膀胱癌T24细胞死亡相关蛋白激酶的转录表达
10.Expression of RECK and matrix metalloprotease-2 in ameloblastoma and their associativityRECK基因和基质金属蛋白酶-2在成釉细胞瘤的表达及相关性研究
11.Proteinase activated receptor-2 promotes IL-4 release from mast cells蛋白酶激活受体2介导肥大细胞IL-4分泌
12.Cloning of Bovine Interleukin-1 Receptor-associated Kinase 2(IRAK2) Gene and Its Bio-information Analysis牛白细胞介素1受体相关激酶2(IRAK2)基因的克隆及生物信息学分析
13.The Expression of NF-κB and Correlative Factor in HK-2 Cells Stimulated by Urinary Protein of Patients with Lupus Nephritis;狼疮肾炎患者尿蛋白刺激人HK-2细胞NF-κB及其相关因子的表达
14.Study of PKC Enzymatic Activity in Multidrug Resistance of Human Renal Cell Carcinoma;蛋白激酶C（PKC）与肾细胞癌多药耐药相关性的研究
15.Investigation on the Expression and Relative Mechanism of cGMP Dependent Protein Kinase Ⅱ in Cancer Cells;Ⅱ型cGMP依赖性蛋白激酶在癌细胞中表达及相关机制的研究
16.Regulation of Protein Kinases on Signal Pathway in Breast Cancer Cell MCF-7 by Curcumin姜黄素对乳腺癌MCF-7细胞信号传导通路相关蛋白激酶的调节作用
17.Effects of MT1-MMP on collagen metabolism regulated by FRNK in hepatic stellate cells膜型基质金属蛋白酶-1在黏着斑激酶相关非激酶调控肝星状细胞胶原代谢中的作用
18.Role of membrane-type matrix metalloproteinase-1 in apoptosis of hepatic stellate cell induced by focal adhesion kinase-related non-kinase in vitro膜型基质金属蛋白酶1在黏着斑激酶相关非激酶诱导肝星状细胞凋亡中的作用
相关短句/例句
S-phase kinase associated protein 2(Skp2)S期激酶相关蛋白2(Skp2)
3)S-Phase Kinase-Associated Proteins 2 (Skp2)S期激酶相关蛋白(Skp2)
4)S-phase kinase associated protein 2细胞周期S期激酶相关蛋白2
5)Skp2细胞S期激酶相关蛋白2
6)Skp2S期激酶相关蛋白2
1.Results The positivity rate ofSkp2 in RCC was significantly higher than that in normal renal tissues (P=0.目的检测S期激酶相关蛋白2(Skp2)和抑癌基因p27kip1在肾细胞癌(RCC)中的表达,探讨其与肾细胞癌生物学特征的关系及意义。
2.BACKGROUND & OBJECTIVE: S-phase kinase-associatedprotein 2 (Skp2) is a positive regulator of G1-S transition and promotesubiquitin-mediated proteolysis of cyclin-dependent kinase inhibitor P27.背景与目的:S期激酶相关蛋白2(S-phaseKinase-associatedProtein2,Skp2)促进泛素介导的细胞周期素依赖激酶抑制剂P27蛋白降解,是细胞G1-S期转化所必需。
3.Objective To study the expression ofSkp2 and p27 in breast cancer and indicate its signicance and corrlativity with each other.目的观察乳腺癌中S期激酶相关蛋白2(S-phase kinase associated protein2,Skp2)、细胞周期调控因子p27的表达情况,探讨它们在乳腺癌中表达的意义及相互关系。
延伸阅读
[3-(aminosulfonyl)-4-chloro-N-(2.3-dihydro-2-methyl-1H-indol-1-yl)benzamide]分子式：C16H16ClN3O3S分子量：365.5CAS号：26807-65-8性质：暂无制备方法：暂无用途：用于轻、中度原发性高血压。
